APPL1

Across TCGA patient cohorts, APPL1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APPL1-associated genes across cancer lineages are Notch1, 14-3-3_beta, and eEF2. Each is linked with APPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both APPL1-to-partner and partner-to-APPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by APPL1-low versus APPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL1→partner) and Y-score (partner→APPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.190	+3.100	<.001	<.001	3	3
COAD	14-3-3_beta →	-0.295	-3.296	.002	.010	3	2
UCEC	eEF2 →	+0.367	+1.938	.001	.001	3	2
COAD	EGFR_pY1068 →	-0.510	-3.169	<.001	.017	3	2
COAD	GAPDH →	+0.790	+3.012	<.001	.018	3	2
COAD	N-Ras →	-0.179	-3.313	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Notch1 by APPL1 expression — UCEC

Explore this box plot interactively →