APPL1

Across TCGA cell cohorts, APPL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,534 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APPL1-associated GO terms across cancer lineages are Mitotic spindle assembly, Positive regulation of pinocytosis, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with APPL1 in more than 18 cancer types. Because this analysis shows association rather than direction, both APPL1-to-partner and partner-to-APPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle assembly grouped by APPL1-low versus APPL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL1→partner) and Y-score (partner→APPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Mitotic spindle assembly →	+0.126	+0.925	<.001	.001	3	19
LUNG_NSCLC_LUSC	Positive regulation of pinocytosis →	+0.167	+1.084	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Regulation of metaphase/anaphase transition of cell cycle →	+0.150	+0.771	<.001	.005	3	17
OVARY	Microtubule cytoskeleton organization involved in mitosis →	+0.090	+1.020	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Regulation of mitotic metaphase/anaphase transition →	+0.160	+0.917	<.001	.001	3	17
LUNG_NSCLC_LUSC	Regulation of chromosome segregation →	+0.151	+0.902	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,534 associations by consensus.

Mitotic spindle assembly by APPL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →