APPL1

Across TCGA cell cohorts, APPL1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APPL1-associated genes across cancer lineages are FAM47A, NR2E1, and CPN1. Each is linked with APPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APPL1-to-partner and partner-to-APPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47A grouped by APPL1-low versus APPL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPL1→partner) and Y-score (partner→APPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM47A →	+0.031	+4.922	<.001	.009	3	2
BLOOD_Lymphoma	NR2E1 →	+0.028	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	CPN1 →	+0.134	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	SPATA16 →	+0.193	+4.321	<.001	.002	3	1
BLOOD_Lymphoma	ASB11 →	+0.039	+4.765	<.001	<.001	3	1
BLOOD_Lymphoma	AGTR2 →	+0.013	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

FAM47A by APPL1 expression — BLOOD_Leukemia

Explore this box plot interactively →