APPBP2

Across TCGA pan-cancer cohorts, APPBP2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated APPBP2 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher APPBP2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated APPBP2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where APPBP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	24	view →
CCRCC	DFS	Tertile	II,III,IV	0.784	0.301	.002	12	view →
LSCC	OS	Median	All	1.000	0.767	.023	2	view →
LUAD	DFS	Median	II,III,IV	0.648	0.262	.045	2	view →
HNSC	DFS	Quartile	All	0.603	0.934	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

APPBP2–UCEC (OS)

Open the UCEC breakdown →