APPBP2

Across TCGA patient cohorts, APPBP2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,346 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APPBP2-associated genes across cancer lineages are MIF4GD, COA3, and SLC4A11. Each is linked with APPBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both APPBP2-to-partner and partner-to-APPBP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APPBP2 versus MIF4GD in HNSC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPBP2→partner) and Y-score (partner→APPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIF4GD →	+1.106	+0.423	.005	.003	3	3
HNSC	COA3 →	+0.962	+0.324	.004	.001	3	3
BRCA	SLC4A11 →	-1.148	-0.440	.002	.002	3	2
GBM	PPP1R27 →	+0.423	+0.231	<.001	.002	3	2
UCEC	MACROD2-AS1 →	+0.768	+0.192	.001	.001	3	2
BRCA	FBXL20 →	+0.498	+0.284	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,346 associations by consensus.

APPBP2 vs MIF4GD — HNSC

Explore this scatter interactively →