APPBP2

Across TCGA patient cohorts, APPBP2 mutation is significantly associated with the RNA expression of many other genes, with 2,955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APPBP2-associated genes across cancer lineages are RNA5SP411, AEN, and RNU6-1082P. Each is linked with APPBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APPBP2-to-partner and partner-to-APPBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by APPBP2-low versus APPBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPBP2→partner) and Y-score (partner→APPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.736	+1.461	<.001	.009	3	2
UCEC	AEN →	+0.687	+2.136	<.001	<.001	3	2
LIHC	RNU6-1082P →	+0.339	+5.108	<.001	.008	3	2
UCEC	OR7E101P →	+0.157	+1.601	.007	.003	3	2
UCEC	IDH1-AS1 →	+0.548	+2.024	<.001	.005	3	2
UCEC	RNA5SP418 →	+0.550	+1.509	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,955 associations by consensus.

RNA5SP411 by APPBP2 expression — UCEC

Explore this box plot interactively →