APPBP2

Across TCGA patient cohorts, APPBP2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APPBP2-associated genes across cancer lineages are JNK_pT183_Y185, p70-S6K_pT389, and Shc_pY317. Each is linked with APPBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APPBP2-to-partner and partner-to-APPBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by APPBP2-low versus APPBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APPBP2→partner) and Y-score (partner→APPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.139	-1.234	.015	.045	3	2
UCEC	p70-S6K_pT389 →	-0.200	-2.700	.001	.005	3	2
UCEC	Shc_pY317 →	-0.159	-2.321	.002	.005	3	2
UCEC	TFRC →	+0.464	+1.906	.010	.015	3	2
UCEC	TIGAR →	+0.126	+1.541	.015	.009	3	2
UCEC	VEGFR2 →	+0.264	+1.817	.009	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK_pT183_Y185 by APPBP2 expression — UCEC

Explore this box plot interactively →