APPBP2

Across TCGA cell cohorts, APPBP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,442 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APPBP2-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, Cytosolic transport, and Regulation of organelle assembly. Each is linked with APPBP2 in more than 19 cancer types. Because this analysis shows association rather than direction, both APPBP2-to-partner and partner-to-APPBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by APPBP2-low versus APPBP2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APPBP2→partner) and Y-score (partner→APPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of beige fat cell differentiation →	+0.191	+1.126	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.103	+1.489	<.001	<.001	3	18
STOMACH	Regulation of organelle assembly →	+0.064	+0.990	.003	.001	3	18
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.076	+1.357	<.001	<.001	3	18
STOMACH	Retrograde transport, endosome to Golgi →	+0.096	+1.107	<.001	.006	3	17
LUNG_NSCLC_LUSC	Mitotic cytokinesis →	+0.104	+1.392	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,442 associations by consensus.

Negative regulation of beige fat cell differentiation by APPBP2 expression — LIVER

Explore this box plot interactively →