APP

Across TCGA patient cohorts, APP RNA expression is significantly associated with the protein abundance of many other proteins, with 7,334 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APP-associated proteins across cancer lineages are POFUT2, CHPF, and PGM2L1. Each is linked with APP in more than 4 cancer types. Because this analysis shows association rather than direction, both APP-to-partner and partner-to-APP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APP versus POFUT2 in LSCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APP→partner) and Y-score (partner→APP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POFUT2 →	+0.404	+0.638	<.001	<.001	3	5
LSCC	CHPF →	+0.322	+0.603	<.001	<.001	3	4
LSCC	PGM2L1 →	+0.469	+0.591	.001	<.001	2	5
LSCC	SLC12A4 →	+0.266	+0.430	<.001	<.001	3	4
HNSC	ITGB1 →	+0.387	+0.613	<.001	.001	3	4
LUAD	NSD3_S561 →	-0.805	-0.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,334 associations by consensus.

APP vs POFUT2 — LSCC

Explore this scatter interactively →