APP

Across TCGA patient cohorts, APP mutation is significantly associated with the RNA expression of many other genes, with 4,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APP-associated genes across cancer lineages are PARPBP, MICU1, and SDHB. Each is linked with APP in more than 2 cancer types. Because this analysis shows association rather than direction, both APP-to-partner and partner-to-APP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARPBP grouped by APP-low versus APP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APP→partner) and Y-score (partner→APP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PARPBP →	+0.430	+1.847	.001	<.001	3	3
UCEC	MICU1 →	+0.237	+2.180	.007	.001	3	3
SKCM	SDHB →	+0.481	+2.839	.002	.001	3	3
UCEC	DCLRE1B →	+0.401	+2.343	<.001	<.001	3	3
UCEC	STIL →	+0.347	+1.786	.007	.007	3	3
LUAD	RNU2-28P →	+0.651	+3.909	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,450 associations by consensus.

PARPBP by APP expression — UCEC

Explore this box plot interactively →