APP

Across TCGA cell cohorts, APP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,326 significant associations in total. CNS shows the largest number of these associations.

The most reproducible APP-associated GO terms across cancer lineages are Actin filament depolymerization, Retrograde transport, endosome to Golgi, and Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. Each is linked with APP in more than 13 cancer types. Because this analysis shows association rather than direction, both APP-to-partner and partner-to-APP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by APP-low versus APP-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APP→partner) and Y-score (partner→APP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Actin filament depolymerization →	+0.152	+1.212	<.001	<.001	3	14
STOMACH	Retrograde transport, endosome to Golgi →	+0.092	+0.954	<.001	.002	3	13
BLOOD_Leukemia	Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway →	+0.219	+3.019	<.001	<.001	3	13
PANCREAS	ERAD pathway →	+0.092	+0.936	<.001	.001	3	13
BONE	Lysosomal transport →	+0.071	+0.962	.003	.001	3	13
SKIN	Endosomal transport →	+0.054	+0.689	<.001	.009	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,326 associations by consensus.

Actin filament depolymerization by APP expression — BREAST

Explore this box plot interactively →