APP-DT

Across TCGA pan-cancer cohorts, APP-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated APP-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher APP-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated APP-DT expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, KIRP, and STAD are the cancer types where APP-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.734	0.530	<.001	94	view →
KIRP	DFS	Quartile	All	1.000	0.478	.001	37	view →
STAD	OS	Quartile	IV	0.788	0.205	<.001	33	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.593	.004	29	view →
ACC	OS	Median	All	0.895	0.696	.007	26	view →
GBM	DFS	Tertile	All	0.135	0.494	<.001	24	view →
CESC	DFS	Tertile	II,III,IV	0.671	0.854	.009	24	view →
LUSC	OS	Tertile	All	0.910	0.715	.018	15	view →
MESO	OS	Median	All	0.636	0.461	.012	13	view →
UVM	DFS	Median	All	0.399	0.699	.009	13	view →
ESCA	OS	Quartile	II,III,IV	0.737	0.452	.014	12	view →
DLBC	OS	Median	III,IV	0.272	1.000	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

APP-DT–KIRC (OS)

Open the KIRC breakdown →