APOOP1

Across TCGA pan-cancer cohorts, APOOP1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated APOOP1 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher APOOP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOOP1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and KIRP show a favorable association.

DLBC, BLCA, and STAD are the cancer types where APOOP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	III,IV	0.063	0.766	<.001	72	view →
BLCA	OS	Tertile	IV	0.284	0.604	.001	54	view →
STAD	DFS	Tertile	All	0.534	0.755	.008	45	view →
LIHC	DFS	Tertile	All	0.170	0.540	.002	42	view →
THYM	OS	Tertile	All	0.627	0.977	.001	36	view →
ACC	OS	Tertile	All	0.197	0.641	.008	36	view →
READ	DFS	Tertile	All	0.027	0.845	<.001	36	view →
LUAD	OS	Tertile	All	0.425	0.685	.001	33	view →
ESCA	DFS	Tertile	III,IV	0.590	0.270	.019	30	view →
OV	OS	Tertile	III,IV	0.541	0.695	.021	30	view →
KIRP	DFS	Median	II,III,IV	0.873	0.352	.008	28	view →
LGG	OS	Tertile	All	0.180	0.468	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

APOOP1–DLBC (DFS)

Open the DLBC breakdown →