APOOL

Across TCGA pan-cancer cohorts, APOOL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated APOOL data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher APOOL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated APOOL expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where APOOL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.913	.014	42	view →
HNSC	DFS	Tertile	III,IV	0.892	0.595	.005	21	view →
CCRCC	DFS	Median	IV	0.233	1.000	.008	18	view →
LSCC	DFS	Median	All	0.559	0.944	.005	15	view →
PDAC	DFS	Median	All	0.671	0.911	.003	15	view →
GBM	OS	Tertile	All	0.440	0.650	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

APOOL–COAD (DFS)

Open the COAD breakdown →