APOOL

Across TCGA patient cohorts, APOOL protein abundance is significantly associated with the RNA expression of many other genes, with 10,005 significant associations in total. COAD shows the largest number of these associations.

The most reproducible APOOL-associated genes across cancer lineages are KIF11, KIF14, and NCAPH. Each is linked with APOOL in more than 5 cancer types. Because this analysis shows association rather than direction, both APOOL-to-partner and partner-to-APOOL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOOL versus KIF11 in OV, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOOL→partner) and Y-score (partner→APOOL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KIF11 →	-0.791	-0.305	<.001	.001	3	6
BRCA	KIF14 →	-0.888	-0.305	<.001	<.001	3	5
BRCA	NCAPH →	-0.680	-0.278	<.001	<.001	3	5
OV	STIL →	-0.988	-0.374	<.001	.001	3	5
COAD	CDCA4 →	-0.908	-0.412	<.001	<.001	3	5
OV	HASPIN →	-0.628	-0.286	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,005 associations by consensus.

APOOL vs KIF11 — OV

Explore this scatter interactively →