APOOL

Across TCGA cell cohorts, APOOL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,609 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOOL-associated GO terms across cancer lineages are Sex-chromosome dosage compensation, Dosage compensation by inactivation of X chromosome, and Negative regulation of protein ubiquitination. Each is linked with APOOL in more than 13 cancer types. Because this analysis shows association rather than direction, both APOOL-to-partner and partner-to-APOOL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sex-chromosome dosage compensation grouped by APOOL-low versus APOOL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOOL→partner) and Y-score (partner→APOOL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Sex-chromosome dosage compensation →	+0.119	+1.179	.001	.001	3	14
LUNG_NSCLC_LUSC	Dosage compensation by inactivation of X chromosome →	+0.110	+1.010	.003	.009	3	14
LUNG_SCLC	Negative regulation of protein ubiquitination →	+0.087	+0.854	<.001	.002	3	14
LUNG_NSCLC_LUSC	Negative regulation of maintenance of sister chromatid cohesion →	+0.201	+1.228	.002	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.201	+1.228	.002	<.001	3	13
LUNG_SCLC	Random inactivation of X chromosome →	+0.108	+0.579	<.001	.003	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,609 associations by consensus.

Sex-chromosome dosage compensation by APOOL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →