Across TCGA patient cohorts, APOO mutation is significantly associated with the RNA expression of many other genes, with 477 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOO-associated genes across cancer lineages are RNA5SP410, MIR5188, and KLF3P2. Each is linked with APOO in more than 1 cancer types. Because this analysis shows association rather than direction, both APOO-to-partner and partner-to-APOO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOO→partner) and Y-score (partner→APOO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP410 →	+0.786	+2.374	<.001	.004	3	2
UCEC	MIR5188 →	+0.720	+2.971	<.001	<.001	3	2
LUSC	KLF3P2 →	+0.197	+5.211	.001	.007	3	2
UCEC	NUTF2P8 →	+0.110	+2.661	<.001	.006	3	1
UCEC	ZNHIT3 →	+0.486	+2.606	.005	.006	3	1
UCEC	RNA5SP414 →	+0.471	+2.407	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 477 associations by consensus.

Exploration

APOO survival (RNA) · tumor vs normal (RNA) · all APOO data types