Across TCGA patient cohorts, APOO mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOO-associated genes across cancer lineages are JNK2, p62 Lck ligand, and AMPK_pT172. Each is linked with APOO in more than 1 cancer types. Because this analysis shows association rather than direction, both APOO-to-partner and partner-to-APOO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOO→partner) and Y-score (partner→APOO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.307	+3.009	.001	.019	3	1
UCEC	p62 Lck ligand →	+0.329	+3.179	.036	.010	3	1
UCEC	AMPK_pT172 →	+0.397	+2.472	.045	.011	3	1
UCEC	Annexin-1 →	+0.819	+3.189	.001	.010	3	1
UCEC	ATM →	-0.624	-3.169	.004	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.813	+3.019	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

APOO survival (RNA) · tumor vs normal (RNA) · all APOO data types