Across TCGA patient cohorts, APOL6 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,255 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APOL6-associated proteins across cancer lineages are PSMB10, PSMB9, and PSME1. Each is linked with APOL6 in more than 9 cancer types. Because this analysis shows association rather than direction, both APOL6-to-partner and partner-to-APOL6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL6→partner) and Y-score (partner→APOL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMB10 →	+0.644	+0.856	<.001	<.001	3	10
UCEC	PSMB9 →	+0.507	+0.619	<.001	<.001	3	10
HNSC	PSME1 →	+0.441	+1.324	<.001	<.001	3	10
HNSC	TYMP →	+0.699	+1.275	<.001	<.001	3	10
UCEC	UBA7 →	+0.470	+0.712	<.001	.001	3	10
HNSC	UBE2L6 →	+0.829	+1.196	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,255 associations by consensus.

Exploration

APOL6 survival (RNA) · tumor vs normal (RNA) · all APOL6 data types