Across TCGA patient cohorts, APOL6 protein abundance is significantly associated with the RNA expression of many other genes, with 7,462 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APOL6-associated genes across cancer lineages are STAT1, GBP5, and CXCL10. Each is linked with APOL6 in more than 6 cancer types. Because this analysis shows association rather than direction, both APOL6-to-partner and partner-to-APOL6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL6→partner) and Y-score (partner→APOL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAT1 →	+1.524	+0.899	.002	.009	3	7
GBM	GBP5 →	+1.793	+0.991	<.001	.002	3	7
GBM	CXCL10 →	+2.814	+0.925	<.001	.005	3	7
CCRCC	CXCL9 →	+2.267	+0.791	<.001	<.001	3	6
BRCA	PLA2G2D →	+1.577	+0.886	.001	.001	3	5
HNSC	SP110 →	+0.903	+0.786	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,462 associations by consensus.

Exploration

APOL6 survival (RNA) · tumor vs normal (RNA) · all APOL6 data types