Across TCGA patient cohorts, APOL6 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOL6-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and FoxM1. Each is linked with APOL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL6-to-partner and partner-to-APOL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL6→partner) and Y-score (partner→APOL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.234	-2.906	.028	.001	3	1
UCEC	eIF4G →	+0.424	+2.700	.001	.006	3	1
UCEC	FoxM1 →	+0.235	+2.906	.032	.001	3	1
UCEC	JNK2 →	+0.229	+3.026	.006	.018	3	1
UCEC	Ku80 →	+0.266	+2.235	.008	.006	3	1
UCEC	MEK1 →	+0.527	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

APOL6 survival (RNA) · tumor vs normal (RNA) · all APOL6 data types