Across TCGA cell cohorts, APOL6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,856 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible APOL6-associated GO terms across cancer lineages are Antigen processing and presentation, Cytolysis in another organism, and Type II interferon-mediated signaling pathway. Each is linked with APOL6 in more than 16 cancer types. Because this analysis shows association rather than direction, both APOL6-to-partner and partner-to-APOL6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL6→partner) and Y-score (partner→APOL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Antigen processing and presentation →	+0.175	+2.178	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Cytolysis in another organism →	+1.876	+2.063	<.001	<.001	3	17
BREAST	Type II interferon-mediated signaling pathway →	+0.282	+2.271	<.001	<.001	3	17
SOFT_TISSUE	Intracellular receptor signaling pathway →	+0.066	+1.860	<.001	<.001	3	17
BREAST	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.300	+2.355	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of peptide antigen via MHC class I →	+0.207	+2.117	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,856 associations by consensus.

Exploration

APOL6 survival (RNA) · tumor vs normal (RNA) · all APOL6 data types