Across TCGA cell cohorts, APOL6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOL6-associated genes across cancer lineages are GJD2, SPESP1, and C20orf85. Each is linked with APOL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL6-to-partner and partner-to-APOL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL6→partner) and Y-score (partner→APOL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SPESP1 →	+0.611	+3.643	.006	.005	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	HCN4 →	+0.033	+3.855	.006	.007	3	1
BLOOD_Leukemia	TRIM43B →	+0.023	+4.234	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

APOL6 survival (RNA) · tumor vs normal (RNA) · all APOL6 data types