APOL3

Across TCGA pan-cancer cohorts, APOL3 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated APOL3 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher APOL3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOL3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where APOL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.881	1.000	.033	30	view →
LUAD	DFS	Median	All	0.745	0.462	.004	20	view →
PDAC	DFS	Quartile	III,IV	0.843	0.410	.024	9	view →
GBM	DFS	Tertile	All	0.268	0.506	.006	8	view →
CCRCC	DFS	Tertile	II,III,IV	0.734	0.420	.011	7	view →
LSCC	DFS	Median	All	0.907	0.464	.009	7	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	2	view →
UCEC	DFS	Tertile	All	0.929	1.000	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

APOL3–COAD (DFS)

Open the COAD breakdown →