APOL3

Across TCGA patient cohorts, APOL3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,301 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APOL3-associated genes across cancer lineages are APOBEC3H, ETV7, and GRAP2. Each is linked with APOL3 in more than 9 cancer types. Because this analysis shows association rather than direction, both APOL3-to-partner and partner-to-APOL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL3 versus APOBEC3H in BRCA, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL3→partner) and Y-score (partner→APOL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APOBEC3H →	+0.891	+0.754	<.001	<.001	3	10
BRCA	ETV7 →	+1.255	+0.744	<.001	<.001	3	10
HNSC	GRAP2 →	+0.994	+0.809	<.001	<.001	3	10
BRCA	IL2RB →	+1.277	+0.710	<.001	<.001	3	10
BRCA	GZMH →	+1.429	+0.775	<.001	<.001	3	10
BRCA	SLA2 →	+1.149	+0.825	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,301 associations by consensus.

APOL3 vs APOBEC3H — BRCA

Explore this scatter interactively →