APOL3

Across TCGA patient cohorts, APOL3 mutation is significantly associated with the RNA expression of many other genes, with 1,034 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOL3-associated genes across cancer lineages are IGLV3-7, TAF9, and PHF5A. Each is linked with APOL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL3-to-partner and partner-to-APOL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLV3-7 grouped by APOL3-low versus APOL3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL3→partner) and Y-score (partner→APOL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGLV3-7 →	+0.277	+5.409	<.001	.005	3	2
UCEC	TAF9 →	+0.621	+3.700	<.001	.001	3	2
SKCM	PHF5A →	+0.373	+2.260	.008	.005	3	2
SKCM	ERGIC1 →	+0.383	+2.826	.005	.001	3	2
SKCM	RAD23B →	+0.418	+2.241	.007	.005	3	2
UCEC	PLS1 →	+0.932	+2.609	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,034 associations by consensus.

IGLV3-7 by APOL3 expression — BRCA

Explore this box plot interactively →