APOL3

Across TCGA cell cohorts, APOL3 mutation is significantly associated with the mutation status of many other genes, with 1,167 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOL3-associated genes across cancer lineages are COL4A4, ECD, and ICAM1. Each is linked with APOL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL3-to-partner and partner-to-APOL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL4A4 grouped by APOL3-low versus APOL3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL3→partner) and Y-score (partner→APOL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COL4A4 →	+1.846	+3.736	.005	.005	1	2
BLOOD_Leukemia	ECD →	+3.050	+3.247	.008	.008	1	2
BLOOD_Leukemia	ICAM1 →	+3.050	+3.247	.008	.008	1	2
SKIN	VPS53 →	+3.772	+3.772	.003	.003	1	2
SKIN	MST1R →	+3.772	+3.772	.003	.003	1	2
BLOOD_Leukemia	GRIN2D →	+3.313	+3.430	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,167 associations by consensus.

COL4A4 by APOL3 expression — SKIN

Explore this box plot interactively →