APOL1

Across TCGA patient cohorts, APOL1 RNA expression is significantly associated with the RNA expression of many other genes, with 16,353 significant associations in total. UVM shows the largest number of these associations.

The most reproducible APOL1-associated genes across cancer lineages are GBP1, APOL3, and GBP4. Each is linked with APOL1 in more than 33 cancer types. Because this analysis shows association rather than direction, both APOL1-to-partner and partner-to-APOL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL1 versus GBP1 in SKCM, with a Pearson correlation of 0.83.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL1→partner) and Y-score (partner→APOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GBP1 →	+2.767	+2.418	<.001	<.001	3	34
SARC	APOL3 →	+2.251	+2.106	<.001	<.001	3	34
SKCM	GBP4 →	+2.765	+2.278	<.001	<.001	3	34
DLBC	APOL6 →	+2.003	+1.168	<.001	<.001	3	34
SKCM	IRF1 →	+2.063	+2.519	<.001	<.001	3	33
OV	APOL2 →	+1.395	+2.011	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,353 associations by consensus.

APOL1 vs GBP1 — SKCM

Explore this scatter interactively →