APOL1

Across TCGA patient cohorts, APOL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,003 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APOL1-associated proteins across cancer lineages are APOL2, IFI35, and UBE2L6. Each is linked with APOL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both APOL1-to-partner and partner-to-APOL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL1 versus APOL2 in CCRCC, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL1→partner) and Y-score (partner→APOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	APOL2 →	+1.019	+1.805	<.001	<.001	3	10
UCEC	IFI35 →	+0.463	+1.099	<.001	<.001	3	9
COAD	UBE2L6 →	+0.698	+1.061	<.001	<.001	3	9
GBM	NMI →	+0.412	+0.928	<.001	<.001	3	9
HNSC	TRIM21 →	+0.493	+0.974	<.001	.002	3	9
OV	CASP4 →	+0.588	+1.989	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,003 associations by consensus.

APOL1 vs APOL2 — CCRCC

Explore this scatter interactively →