APOL1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, APOL1 protein abundance is significantly associated with the protein abundance of many other proteins, with 19,166 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOL1-associated proteins across cancer lineages are APOA1, APOA2, and APOB. Each is linked with APOL1 in more than 8 cancer types. Because this analysis shows association rather than direction, both APOL1-to-partner and partner-to-APOL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL1 versus APOA1 in CCRCC, with a Pearson correlation of 0.77.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL1→partner) and Y-score (partner→APOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCAPOA1 →+0.962+0.796<.001<.00139
CCRCCAPOA2 →+0.973+0.748<.001<.00139
GBMAPOB →+0.790+0.794<.001<.00139
CCRCCAPOC1 →+1.022+0.752<.001<.00139
CCRCCAPOC3 →+0.911+0.699<.001<.00139
CCRCCAPOF →+0.777+0.732<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 19,166 associations by consensus.

APOL1 vs APOA1 — CCRCC

Per-sample scatter of APOL1 vs APOA1 in CCRCC (Pearson r = 0.77).

Explore this scatter interactively →

Exploration