APOL1

Across TCGA patient cohorts, APOL1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOL1-associated genes across cancer lineages are eIF4E, Annexin-1, and ASNS. Each is linked with APOL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL1-to-partner and partner-to-APOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by APOL1-low versus APOL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL1→partner) and Y-score (partner→APOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.232	+3.700	.007	.001	3	2
UCEC	Annexin-1 →	+0.746	+2.720	<.001	.003	3	2
UCEC	ASNS →	+0.514	+2.000	<.001	.030	3	2
SKCM	FOXO3a →	-0.109	-3.000	.035	.034	3	1
SKCM	Smac →	+0.344	+2.182	.004	.033	3	1
SKCM	TFRC →	+0.660	+3.321	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by APOL1 expression — UCEC

Explore this box plot interactively →