APOE

Across TCGA pan-cancer cohorts, APOE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated APOE data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher APOE mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOE expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where APOE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.732	1.000	.010	72	view →
PDAC	DFS	Median	All	0.309	0.500	<.001	22	view →
UCEC	DFS	Quartile	All	0.795	1.000	.004	18	view →
CCRCC	DFS	Quartile	All	0.917	0.544	.007	15	view →
LUAD	OS	Tertile	II,III,IV	0.354	1.000	.008	9	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

APOE–COAD (DFS)

Open the COAD breakdown →