APOE

Across TCGA patient cohorts, APOE protein abundance is significantly associated with the RNA expression of many other genes, with 11,115 significant associations in total. COAD shows the largest number of these associations.

The most reproducible APOE-associated genes across cancer lineages are BCL2A1, LAIR1, and MSR1. Each is linked with APOE in more than 7 cancer types. Because this analysis shows association rather than direction, both APOE-to-partner and partner-to-APOE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOE versus BCL2A1 in GBM, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOE→partner) and Y-score (partner→APOE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCL2A1 →	+1.434	+0.542	<.001	.001	3	8
OV	LAIR1 →	+0.897	+0.514	<.001	.002	3	8
GBM	MSR1 →	+1.282	+0.576	<.001	.003	3	8
UCEC	GPNMB →	+0.998	+0.432	<.001	.004	3	8
GBM	CD33 →	+0.761	+0.566	<.001	<.001	2	8
OV	CD4 →	+1.028	+0.497	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,115 associations by consensus.

APOE vs BCL2A1 — GBM

Explore this scatter interactively →