APOE

Across TCGA cell cohorts, APOE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,752 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible APOE-associated GO terms across cancer lineages are Triglyceride-rich lipoprotein particle remodeling, Very-low-density lipoprotein particle remodeling, and Chylomicron remnant clearance. Each is linked with APOE in more than 17 cancer types. Because this analysis shows association rather than direction, both APOE-to-partner and partner-to-APOE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Triglyceride-rich lipoprotein particle remodeling grouped by APOE-low versus APOE-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOE→partner) and Y-score (partner→APOE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Triglyceride-rich lipoprotein particle remodeling →	+1.605	+3.700	<.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	Very-low-density lipoprotein particle remodeling →	+1.531	+2.502	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Chylomicron remnant clearance →	+1.927	+3.052	<.001	.001	3	18
LUNG_NSCLC_LUSC	Triglyceride-rich lipoprotein particle clearance →	+1.927	+3.052	<.001	.001	3	18
STOMACH	AMPA glutamate receptor clustering →	+1.607	+5.819	<.001	<.001	3	18
STOMACH	Glutamate receptor clustering →	+1.607	+5.819	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,752 associations by consensus.

Triglyceride-rich lipoprotein particle remodeling by APOE expression — OESOPHAGUS

Explore this box plot interactively →