APOE

Across TCGA cell cohorts, APOE mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOE-associated genes across cancer lineages are PXDNL, RBMXL2, and RIPPLY2. Each is linked with APOE in more than 1 cancer types. Because this analysis shows association rather than direction, both APOE-to-partner and partner-to-APOE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PXDNL grouped by APOE-low versus APOE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOE→partner) and Y-score (partner→APOE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PXDNL →	+0.126	+4.363	<.001	<.001	3	1
LARGE_INTESTINE	RBMXL2 →	+0.073	+2.817	<.001	.007	3	1
LARGE_INTESTINE	RIPPLY2 →	+0.379	+2.933	<.001	.003	3	1
LARGE_INTESTINE	KCNU1 →	+0.044	+3.345	<.001	.001	3	1
LARGE_INTESTINE	F11 →	+0.049	+2.882	<.001	.005	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PXDNL by APOE expression — LARGE_INTESTINE

Explore this box plot interactively →