APOC2

Across TCGA cell cohorts, APOC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,585 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOC2-associated GO terms across cancer lineages are Chylomicron remodeling, Negative regulation of calcineurin-NFAT signaling cascade, and Negative regulation of calcineurin-mediated signaling. Each is linked with APOC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both APOC2-to-partner and partner-to-APOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chylomicron remodeling grouped by APOC2-low versus APOC2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC2→partner) and Y-score (partner→APOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Chylomicron remodeling →	+1.907	+4.485	<.001	<.001	3	6
LIVER	Negative regulation of calcineurin-NFAT signaling cascade →	-0.254	-5.197	<.001	<.001	3	5
LIVER	Negative regulation of calcineurin-mediated signaling →	-0.254	-5.197	<.001	<.001	3	5
LIVER	Regulation of low-density lipoprotein particle receptor catabolic process →	+0.147	+3.271	.004	.009	3	5
LIVER	Triglyceride-rich lipoprotein particle remodeling →	+0.943	+3.916	.005	.001	3	5
BLOOD_Leukemia	Regulation of very-low-density lipoprotein particle remodeling →	+1.648	+4.289	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,585 associations by consensus.

Chylomicron remodeling by APOC2 expression — LIVER

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