APOBEC4

Across TCGA pan-cancer cohorts, APOBEC4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated APOBEC4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher APOBEC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated APOBEC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, LIHC, and UCEC are the cancer types where APOBEC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	IV	0.091	0.593	<.001	18	view →
LIHC	DFS	Median	All	0.026	0.556	<.001	18	view →
UCEC	DFS	Median	All	1.000	0.636	.038	4	view →
LUAD	OS	Median	All	0.176	0.670	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

APOBEC4–CESC (OS)

Open the CESC breakdown →