APOBEC3B

Across TCGA patient cohorts, APOBEC3B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC3B-associated genes across cancer lineages are 4E-BP1, FOXO3a_pS318_S321, and ACC1. Each is linked with APOBEC3B in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3B-to-partner and partner-to-APOBEC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by APOBEC3B-low versus APOBEC3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3B→partner) and Y-score (partner→APOBEC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.336	+3.906	.004	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.124	-3.312	.022	.010	3	1
UCEC	ACC1 →	+0.337	+2.820	.033	.035	3	1
UCEC	ACVRL1 →	-0.148	-2.986	.013	.035	3	1
UCEC	mTOR_pS2448 →	-0.170	-3.302	.009	.010	3	1
UCEC	Notch1 →	+0.198	+3.183	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

4E-BP1 by APOBEC3B expression — UCEC

Explore this box plot interactively →