APOBEC3B

Across TCGA cell cohorts, APOBEC3B mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBEC3B-associated genes across cancer lineages are MYF6, OR1L6, and OR2J2. Each is linked with APOBEC3B in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3B-to-partner and partner-to-APOBEC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by APOBEC3B-low versus APOBEC3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3B→partner) and Y-score (partner→APOBEC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR2J2 →	+0.024	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TAS2R39 →	+0.019	+4.467	.007	.004	3	1
LARGE_INTESTINE	OR5V1 →	+0.010	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MYF6 by APOBEC3B expression — LARGE_INTESTINE

Explore this box plot interactively →