APOBEC3B-AS1

Across TCGA pan-cancer cohorts, APOBEC3B-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated APOBEC3B-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher APOBEC3B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated APOBEC3B-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

KICH, BLCA, and HNSC are the cancer types where APOBEC3B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	III,IV	0.204	0.761	.004	54	view →
BLCA	OS	Tertile	IV	0.335	0.649	.012	48	view →
HNSC	OS	Quartile	II,III,IV	0.494	0.295	.005	45	view →
BRCA	DFS	Tertile	IV	0.175	0.730	.005	36	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	36	view →
KIRC	DFS	Tertile	II,III,IV	0.398	0.680	.012	30	view →
OV	OS	Tertile	III,IV	0.917	0.817	.020	18	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
LUAD	DFS	Tertile	IV	0.333	0.671	.048	18	view →
COAD	DFS	Tertile	IV	0.244	0.509	.012	18	view →
SKCM	DFS	Tertile	IV	1.000	0.241	.021	15	view →
THCA	DFS	Tertile	All	0.899	0.806	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

APOBEC3B-AS1–KICH (OS)

Open the KICH breakdown →