APOBEC3AP1

Across TCGA pan-cancer cohorts, APOBEC3AP1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of APOBEC3AP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where APOBEC3AP1 RNA is repressed in tumor relative to normal tissue. In most cancer types APOBEC3AP1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and PRAD are the cancer types where APOBEC3AP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOBEC3AP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.579	<.001	9	view →
LUSC	Male	II,III,IV	−1.051	<.001	8	view →
PRAD	All	All	+0.602	<.001	2	view →
THCA	Male	All	+0.062	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

APOBEC3AP1–LUAD

Open the LUAD breakdown →