APOBEC3A

Across TCGA cell cohorts, APOBEC3A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBEC3A-associated GO terms across cancer lineages are Defense response to bacterium, Negative regulation of innate immune response, and Response to indole-3-methanol. Each is linked with APOBEC3A in more than 6 cancer types. Because this analysis shows association rather than direction, both APOBEC3A-to-partner and partner-to-APOBEC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Defense response to bacterium grouped by APOBEC3A-low versus APOBEC3A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3A→partner) and Y-score (partner→APOBEC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Defense response to bacterium →	+0.099	+1.112	<.001	.008	3	7
LARGE_INTESTINE	Negative regulation of innate immune response →	+0.063	+0.167	<.001	<.001	3	7
LARGE_INTESTINE	Response to indole-3-methanol →	+0.104	+0.204	<.001	.001	3	7
LARGE_INTESTINE	Cellular response to indole-3-methanol →	+0.070	+0.182	.006	<.001	3	7
LARGE_INTESTINE	Regulation of synoviocyte proliferation →	-0.168	-0.208	<.001	.001	3	6
LARGE_INTESTINE	Positive regulation of synoviocyte proliferation →	-0.168	-0.208	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,344 associations by consensus.

Defense response to bacterium by APOBEC3A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →