APOBEC3A

Across TCGA cell cohorts, APOBEC3A mutation is significantly associated with the mutation status of many other genes, with 219 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOBEC3A-associated genes across cancer lineages are NOL11, GAREM2, and IRX6. Each is linked with APOBEC3A in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3A-to-partner and partner-to-APOBEC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOL11 grouped by APOBEC3A-low versus APOBEC3A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3A→partner) and Y-score (partner→APOBEC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NOL11 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	GAREM2 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	IRX6 →	+4.736	+5.560	.003	.003	1	2
BLOOD_Leukemia	SPIDR →	+5.321	+5.894	.002	.002	1	2
BLOOD_Leukemia	OR2K2 →	+6.321	+6.321	.001	.001	1	2
BLOOD_Leukemia	FBXL5 →	+4.736	+5.560	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 219 associations by consensus.

NOL11 by APOBEC3A expression — BLOOD_Leukemia

Explore this box plot interactively →