APOBEC2

Across TCGA patient cohorts, APOBEC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,771 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible APOBEC2-associated proteins across cancer lineages are EEF2_S502, OSBPL3, and SUGP2. Each is linked with APOBEC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both APOBEC2-to-partner and partner-to-APOBEC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOBEC2 versus EEF2_S502 in HNSC, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC2→partner) and Y-score (partner→APOBEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EEF2_S502 →	-0.648	-1.208	<.001	<.001	3	4
GBM	OSBPL3 →	-0.281	-0.461	.005	.001	3	4
GBM	SUGP2 →	+0.298	+0.450	.006	.004	3	4
OV	SHARPIN_S165 →	-0.492	-0.304	.001	.003	3	4
HNSC	SNTA1 →	+0.857	+1.406	<.001	<.001	3	4
PDAC	ABLIM1_S426 →	+0.743	+0.887	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,771 associations by consensus.

APOBEC2 vs EEF2_S502 — HNSC

Explore this scatter interactively →