APOBEC2

Across TCGA patient cohorts, APOBEC2 protein abundance is significantly associated with the protein abundance of many other proteins, with 13,492 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible APOBEC2-associated proteins across cancer lineages are ACTN2, MYL3, and ABLIM1_S426. Each is linked with APOBEC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both APOBEC2-to-partner and partner-to-APOBEC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOBEC2 versus ACTN2 in HNSC, with a Pearson correlation of 0.96.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC2→partner) and Y-score (partner→APOBEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ACTN2 →	+1.887	+2.172	<.001	<.001	3	3
HNSC	MYL3 →	+2.160	+1.970	<.001	<.001	3	3
HNSC	ABLIM1_S426 →	+0.769	+1.595	<.001	<.001	3	3
HNSC	SSU72 →	-0.238	-1.391	<.001	<.001	3	3
HNSC	PRKAA2_S491 →	+1.196	+1.405	<.001	<.001	3	3
HNSC	ACTN2_T237 →	+1.988	+1.939	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,492 associations by consensus.

APOBEC2 vs ACTN2 — HNSC

Explore this scatter interactively →