APOBEC2

Across TCGA patient cohorts, APOBEC2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC2-associated genes across cancer lineages are 4E-BP1, FoxM1, and HSP70. Each is linked with APOBEC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC2-to-partner and partner-to-APOBEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by APOBEC2-low versus APOBEC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC2→partner) and Y-score (partner→APOBEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.312	+3.029	.013	.018	3	2
UCEC	FoxM1 →	+0.240	+2.999	.047	.035	3	1
UCEC	HSP70 →	-0.405	-2.990	.030	.036	3	1
UCEC	MEK1 →	+0.475	+3.700	.005	.001	3	1
UCEC	p62 Lck ligand →	+0.454	+3.700	.002	.001	1	1
UCEC	Rad50 →	-0.243	-3.700	.031	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

4E-BP1 by APOBEC2 expression — UCEC

Explore this box plot interactively →