APOBEC2

Across TCGA cell cohorts, APOBEC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,375 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible APOBEC2-associated GO terms across cancer lineages are Oxidative demethylation, Negative regulation of brown fat cell differentiation, and Negative regulation of gene expression, epigenetic. Each is linked with APOBEC2 in more than 8 cancer types. Because this analysis shows association rather than direction, both APOBEC2-to-partner and partner-to-APOBEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative demethylation grouped by APOBEC2-low versus APOBEC2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC2→partner) and Y-score (partner→APOBEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Oxidative demethylation →	-0.245	-0.090	.005	<.001	3	9
BLOOD_Lymphoma	Negative regulation of brown fat cell differentiation →	+0.156	+0.388	<.001	.003	3	8
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.058	+1.676	.005	.002	3	8
SOFT_TISSUE	Oocyte growth →	+0.123	+1.188	.003	.009	3	8
SOFT_TISSUE	Negative regulation of mRNA metabolic process →	+0.082	+1.980	<.001	<.001	3	8
BREAST	Protein localization to cytoplasmic stress granule →	+0.100	+0.116	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,375 associations by consensus.

Oxidative demethylation by APOBEC2 expression — BREAST

Explore this box plot interactively →