APOBEC2

Across TCGA cell cohorts, APOBEC2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBEC2-associated genes across cancer lineages are GUCA1C, KCTD8, and LBHD2. Each is linked with APOBEC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC2-to-partner and partner-to-APOBEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1C grouped by APOBEC2-low versus APOBEC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC2→partner) and Y-score (partner→APOBEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GUCA1C →	+0.123	+4.095	.008	.009	3	1
LARGE_INTESTINE	KCTD8 →	+0.188	+4.095	.002	.009	3	1
LARGE_INTESTINE	LBHD2 →	+0.130	+4.273	<.001	.006	3	1
LARGE_INTESTINE	GSC2 →	+0.168	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GUCA1C by APOBEC2 expression — LARGE_INTESTINE

Explore this box plot interactively →