APOA4

Across TCGA pan-cancer cohorts, APOA4 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of APOA4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where APOA4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types APOA4 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where APOA4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOA4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.353	<.001	11	view →
COAD	Male	All	−1.132	<.001	11	view →
LUAD	Female	III,IV	−1.255	<.001	9	view →
LSCC	All	All	−1.134	<.001	8	view →
CCRCC	Male	III,IV	−0.540	.002	6	view →
PDAC	All	All	+0.592	<.001	4	view →
OV	All	All	−0.950	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

APOA4–HNSC

Open the HNSC breakdown →