APOA4

Across TCGA patient cohorts, APOA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,503 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible APOA4-associated GO terms across cancer lineages are Regulation of very-low-density lipoprotein particle remodeling, Coenzyme A metabolic process, and Proton motive force-driven ATP synthesis. Each is linked with APOA4 in more than 7 cancer types. Because this analysis shows association rather than direction, both APOA4-to-partner and partner-to-APOA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of very-low-density lipoprotein particle remodeling grouped by APOA4-low versus APOA4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA4→partner) and Y-score (partner→APOA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of very-low-density lipoprotein particle remodeling →	+0.739	+0.934	<.001	<.001	3	8
ESCA	Coenzyme A metabolic process →	+0.041	+0.741	<.001	.001	3	7
STAD	Proton motive force-driven ATP synthesis →	+0.034	+0.880	.001	<.001	3	7
STAD	Obsolete negative regulation of mitochondrion organization →	+0.032	+0.804	<.001	<.001	3	7
ESCA	Water-soluble vitamin biosynthetic process →	+0.051	+0.848	<.001	.004	3	7
ESCA	Dicarboxylic acid metabolic process →	+0.035	+1.255	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,503 associations by consensus.

Regulation of very-low-density lipoprotein particle remodeling by APOA4 expression — ESCA

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